Research progress on the mechanism of flagellum-mediated oxidative stress response of Campylobacter jejuni

Abstract:

Campylobacter jejuni, a worldwide prevalent food-borne zoonotic pathogen, is a Gram-negative microaerophilic bacterium. It is extremely sensitive to environmental conditions such as oxygen, temperature, pH, and bile salts, and suffers from adverse conditions including lethal reactive oxygen species (ROS) during the spread and colonization. Therefore, the response to ROS is an important strategy for C. jejuni. C. jejuni has evolved a variety of mechanisms to resist oxidative stress, which involve flagella and flagellum-mediated motility. Therefore, we comprehensively expounded the research progress on the mechanisms of C. jejuni in response to oxidative stress, especially that mediated by flagella, aiming to lay a foundation for further improving the regulation system of Campylobacter jejuni in response to oxidative stress and provide information for the prevention and control of Campylobacter at the source.