Progress on the protein secretion system of Gram-negative bacteria

Abstract:

Gram-negative bacteria, such as the commonly used Escherichia coli strains, have poor protein secretion capacities due to their intricate double-layer membrane. This shortcoming limits the production of Gram-negative bacteria for specific biopharmaceuticals and other bioproducts. Therefore, the research on the protein secretion system of Gram-negative bacteria is of great significance. This review summarized the knowledge about protein secretion system of Gram-negative bacteria, including the secretion process, the types of secreted proteins, the structural information of the secretion system, and the technologies for protein secretion research. Thus, this review will provide referential information for studying the protein secretion mechanism in Gram-negative bacteria.