Research progress on phenazine biosynthesis regulated by two-component signal transduction system of Pseudomonas aeruginosa

Abstract:

Phenazine is a class of nitrogen-containing heterocyclic compounds. It is usually a secondary metabolite produced by Pseudomonas or Streptomyces. Phenazine has antibacterial activity, and phenazine also has anti-insect and anti-tumor activity. It is not only widely used in agriculture, but also widely used in medical field. But the synthesis of phenazine is very complex, because it is regulated by a multi-cascade network. In this article, the author will summarize the regulatory mechanism of two-component signal transduction system on phenazine biosynthesis in Pseudomonas. This paper elucidates the effect of small RNA on phenazine biosynthesis under the control of each two-component signal transduction system, and the effect of quorum sensing on phenazine biosynthesis under the control of each two-component signal transduction system. The purpose of this study is to provide a reference for the further study of the cascade network of phenazine synthesis regulated by Pseudomonas.

Key words:Pseudomonas spp.;phenazine;two-component signal transduction system;quorum sensing;small RNA