Progress of adaptive laboratory evolution for industrial strain breeding

Abstract:

Adaptive laboratory evolution is a method of screening mutant strains with specific phenotypes by long-term domestication under certain selection pressure. In recent years, this method has been widely used to screen industrial production strains with excellent characteristics through specific evolutionary conditions and screening strategies, such as specific phenotypic screening, efficient use of substrates, target product synthesis, and growth characteristics optimization. In this review, the typical examples and research progress of adaptive laboratory evolution for the breeding of industrial production strains were summarized, the existing problems and solutions were discussed. The prospect of this technology was also forecasted.