Probiotics in the prevention and treatment of atopic dermatitis

doi:10.13344/j.microbiol.china.210419

Home > Archive>Volume 49, Issue 1, 2022 >283-291. DOI:10.13344/j.microbiol.china.210419

Probiotics in the prevention and treatment of atopic dermatitis
DOI:
                        10.13344/j.microbiol.china.210419
                    
CSTR:
                        32113.14.j.MC.210419
                    
Author:
                        LI XiangLI Xiang
Key Laboratory of Molecular Animal Nutrition of Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China
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WANG FeiWANG Fei
Key Laboratory of Molecular Animal Nutrition of Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China
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XU ShujieXU Shujie
Hainan Institute of Zhejiang University, Sanya 572025, Hainan, China
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LÜ XunfeiLÜ Xunfei
Nanjing Runli Biotechnology Limited Company, Nanjing 211300, Jiangsu, China
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LI WeifenLI Weifen
Key Laboratory of Molecular Animal Nutrition of Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China;Hainan Institute of Zhejiang University, Sanya 572025, Hainan, China
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Abstract:

Atopic dermatitis (AD) is a recurrent, chronic and inflammatory cutaneous disease with a clear genetic predisposition, and its incidence rate is increasing year by year. The main pathogenesis of AD is skin microdysbiosis and allergen leakage caused by hereditary or acquired cutaneous barrier damage, which activate the corresponding inflammatory reaction, resulting in the vicious circle of "barrier damage-inflammatory reaction". The traditional treatment of AD is corticosteroid and immunosuppressants. Recent studies have revealed that probiotics are effective in the treatment of AD. Probiotics can reshape the gut-skin axis by altering the skin or intestinal microbiota and repair of the skin barrier, resulting in stopping the cycle of AD progression and restoring healthy skin homeostasis.

Key words:probiotics;atopic dermatitis;skin barrier;skin microbiota

Reference

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LI Xiang, WANG Fei, XU Shujie, Lü Xunfei, LI Weifen. Probiotics in the prevention and treatment of atopic dermatitis[J]. Microbiology China, 2022, 49(1): 283-291

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