Probiotics in the prevention and treatment of atopic dermatitis

Abstract:

Atopic dermatitis (AD) is a recurrent, chronic and inflammatory cutaneous disease with a clear genetic predisposition, and its incidence rate is increasing year by year. The main pathogenesis of AD is skin microdysbiosis and allergen leakage caused by hereditary or acquired cutaneous barrier damage, which activate the corresponding inflammatory reaction, resulting in the vicious circle of "barrier damage-inflammatory reaction". The traditional treatment of AD is corticosteroid and immunosuppressants. Recent studies have revealed that probiotics are effective in the treatment of AD. Probiotics can reshape the gut-skin axis by altering the skin or intestinal microbiota and repair of the skin barrier, resulting in stopping the cycle of AD progression and restoring healthy skin homeostasis.