Research progress of colorectal cancer related pathogens bacteria

Abstract:

Intestinal microbiota is closely related to colorectal cancer (CRC). The change of intestinal microbial community may be accompanied by the occurrence of CRC, and the emergence of some harmful bacteria may be the direct cause of CRC. Among them, Fusobacterium nucleatum (F. nucleatum), enterotoxigenic Bacteroides fragilis (ETBF) and pks⁺ Escherichia coli (pks⁺ E. coli) were most closely associated with CRC. This review focuses on the pathogenic causes of pks⁺ E. coli and colibactin, the effects on intestinal microbial composition, the synthesis of colibactin and how to inhibit or promote pks⁺ E. coli. At the same time, the possible carcinogenic causes of ETBF and F. nucleatum, their effects on intestinal microbial composition and their promotion or inhibition were also introduced.

Key words:intestinal microflora;colorectal cancer;pks⁺ Escherichia coli;Bacteroides fragilis;Fusobacterium nucleatum