Application and prospect of Meta-analysis in the study of bacterial resistance

Abstract:

With the massive and irregular use of antibiotics, the antibiotic resistance of bacteria continues to increase, leading to the emergence of drug-resistant and multi-drug resistant bacteria, which seriously threaten human health. Therefore, the application of statistical methods to summarize and multi-analyze the research on antibiotic resistance will help to better understand the prevalence and distribution of antibiotic resistance bacteria worldwide, clarify the common problems of the laws and mechanisms of the formation of drug resistance, and provide effective and scientific guidance for prevention and control the breeding and transmission of bacterial resistance. Meta-analysis is a statistical method that comprehensively analyzes multiple studies in the same research field. It has been widely used in the study of bacterial resistance. In this comprehensive review, briefly describes the origin and basic process of Meta-analysis. The bibliometrics was used to systematically and comprehensively analyze the application of Meta-analysis in the study of bacterial antibiotic resistance from 2000 to 2020. Then, we summarized and explained the successful cases and conclusions of Meta-analysis in the field of bacterial resistance. Furthermore, the future research about Meta-analysis in the field of bacterial antibiotic resistance was prospected, for the view of promote the application of this method in the study of bacterial resistance, and provide a reliable tool for the systematic interpretation and effective control of bacterial resistance.