LIU Cong
BGI-Shenzhen, Shenzhen, Guangdong 518083, China;Shenzhen Key Laboratory of Unknown Pathogen Identification, Shenzhen, Guangdong 518083, ChinaXING Bo
BGI-Shenzhen, Shenzhen, Guangdong 518083, China;College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, ChinaCHEN Wantong
BGI-Shenzhen, Shenzhen, Guangdong 518083, China;School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510006, ChinaLI Junhua
BGI-Shenzhen, Shenzhen, Guangdong 518083, China;Shenzhen Key Laboratory of Unknown Pathogen Identification, Shenzhen, Guangdong 518083, ChinaXIAO Minfeng
BGI-Shenzhen, Shenzhen, Guangdong 518083, China;Shenzhen Key Laboratory of Unknown Pathogen Identification, Shenzhen, Guangdong 518083, ChinaThe gut is the largest reservoir of human flora. In the last decade, with the increasing investigations on the relationships between gut microbiota and human health diseases, gut bacteriophage has also drawn more attention. However, the research of gut bacteriophage is still in its infancy, hampered by delayed progress in the experimental and bioinformatical technology for gut bacteriophage and virome. Thus, this review first summarizes the research methodology of gut bacteriophage in computation and experiments, including sequening analysis and phage isolation, etc. Then, phage taxonomy, phage-host interactions, and the clinical applications of gut bacteriophage are also discussed. Finally, this review looks forward to the challenges and opportunities for gut bacteriophage research in data and physical resources, bioinformatical and experimental technology, interactions with intestinal bacteria, interventions on human diseases, etc.
LIU Cong, XING Bo, CHEN Wantong, LI Junhua, XIAO Minfeng. Research and application of human gut bacteriophage[J]. Microbiology China, 2021, 48(9): 3314-3329
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