Research progress on interactions between bacterial quorum sensing system and phage

Abstract:

Bacteria possess a variety of resistant mechanisms against phage infection in the long-term coevolution with phages. Among them, quorum sensing has become a hot topic in recent years as a means for bacteria to resist phage infection. Bacterial quorum sensing mainly depends on bacterial density and regulates the expression of target genes, as well as the infection of phage. Therefore, bacterial quorum sensing is closely related to phage. However, the interactions between quorum sensing and phage are complex and diverse, quorum sensing has been proved to be unfavorable or beneficial to phage infection, and regulates the switch of phage lysis-lysogeny. Therefore, this paper will discuss the role of quorum sensing in phage infection, the decisive role of quorum sensing in phage lysis-lysogeny switch, and the other interactions between quorum sensing and phage, which provides theoretical basis for phage therapy in bacterial diseases.