Advance in the depolymerase employed by Klebsiella pneumoniae phage

Abstract:

Klebsiella pneumoniae is one of the common pathogenic bacteria that causes a variety of clinical infections. The emergence of multi-drug resistant Klebsiella pneumoniae strains has brought numerous obstacles in prevention and control of bacterial infections. The depolymerase encoded by Klebsiella pneumoniae phage is a biological enzyme with high stability and strong specificity. It has many functions such as decomposing bacterial extracellular polysaccharides and restricting the bacterial growth, etc. The depolymerase provides new ideas to prevent and control Klebsiella pneumoniae infection and has broad prospects in antibacterial applications. This article reviews the advance of depolymerase employed by phage of Klebsiella pneumoniae.