Molecular mechanisms of bacterial resistance to bacteriophage infection: a review

doi:10.13344/j.microbiol.china.210483

Home > Archive>Volume 48, Issue 9, 2021 >3249-3260. DOI:10.13344/j.microbiol.china.210483

Molecular mechanisms of bacterial resistance to bacteriophage infection: a review
DOI:
                        10.13344/j.microbiol.china.210483
                    
CSTR:
                        32113.14.j.MC.210483
                    
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                        ZHONG ZhuojunZHONG Zhuojun
Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China
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RAO XiancaiRAO Xiancai
Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China
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LE ShuaiLE Shuai
Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China
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Abstract:

Bacteriophage is the virus that infects bacteria. To resist bacteriophage infections, bacteria have evolved various antiviral mechanisms, which significantly promote the development of gene editing and lay down foundations for bacteriophage treatment. This review briefly concludes the molecular resistance mechanisms of host bacteria against bacteriophage infection. Next, the effects of such defense systems on bacteria physiology and ecology are discussed. Then, we summarized the limitations and future directions of bacteriophage resistance research.

Key words:bacteriophage resistance;gene editing;superinfection exclusion;restriction-modification systems;CRISPR systems;abortive infection;phage-inducible chromosomal islands

Reference

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ZHONG Zhuojun, RAO Xiancai, LE Shuai. Molecular mechanisms of bacterial resistance to bacteriophage infection: a review[J]. Microbiology China, 2021, 48(9): 3249-3260

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Received:May 31,2021
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Adopted:July 01,2021
Online: September 08,2021
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