Gut microbiota-microRNA interaction in colorectal cancer: a review

Abstract:

Colorectal cancer is one of the most common cancers in the western world. Lots of studies suggest a link between gut microbiota dysbiosis and colorectal cancer. And scientists suppose that there is a delicate regulatory network between gut microbiota and the human body. Recently, microRNA has been showed as a crucial mediator of this network. A growing number of studies indicate that gut microbiota can influence the expression and function of human cells' microRNA. In turn, human cells derived microRNA can regulate the gut microbiota ecosystem. Therefore, this review summarizes the specific mechanism of the interaction between gut microbiota and host microRNA, especially focus on the studies related to the occurrence, development, and treatment of colorectal cancer. It can provide the newest insight in the relationship between gut microbiota and colorectal cancer.