Research status of microbial fermentation of Chinese herbal medicine

Abstract:

As a natural traditional medicine, Chinese herbal medicine is widely used in clinical medicine and daily health care because of its characteristics of pure nature, no drug residue and resistance, and little toxic and side effects. In the process of microbial fermentation of Chinese herbal medicine, the cellulose and lignin other substances in the cell-wall are degraded by enzymes produced by microorganisms, and the active components are released; The active components of Chinese herbal medicine are enzymolyzed into substances with small molecular, which could enhance the efficacy and be conducive to digestion and absorption of the body. After fermentation, some Chinese herbal medicines could reduce the toxicity and side effects and even produce new active substances. Meanwhile, some ingredients in Chinese herbs can promote the growth and reproduction of microorganisms. It can be seen that Chinese herbal medicine and microorganism have synergistic effect and complement each other. In this paper, the advantages, common microorganisms, application status, existing problems and key factors of fermentation of Chinese herbal medicine were reviewed, and the application prospect of fermentation of Chinese herbal medicine was prospected. It is believed that with the maturity of fermentation technology and the modern development of Chinese herbal medicine, the microbial fermentation of Chinese herbal medicine will have a broader development potential and application value in the future.

Key words:Chinese herbal medicine, probiotics, microbial fermentation, biotransformation