Effector and molecular mechanism of Legionella pneumophila regulating host ubiquitination pathway: a review

Abstract:

Legionella pneumophila secretes a large number of effectors into the cytoplasm through its unique Dot/Icm type-IVB secretion system, among which there are more than ten effectors known to participate in regulation of host ubiquitination. These effectors achieve the purpose of evading surveillance by the host immune system and proliferation by regulating the host ubiquitination pathway. The effectors involved in regulating the host ubiquitination pathway include AnkB, SidC, LubX, SidH, LegU1, GobX, RavD, DupA, DupB, SidJ, Ceg23, MvcA, MavC and SidE family proteins. Through the gradually in-depth study of the functional experiments and structural biology of these effect factors, their relatively complete molecular mechanism has gradually been revealed. This article reviews several important L. pneumophila effectors and their biological structure and molecular mechanism, which is helpful to comprehensively understand the complex process of Legionella pneumophila involved in regulating the host ubiquitination system.

Key words:Legionella pneumophila, effector, ubiquitination, biological structure, molecular mechanism