Progress of essential genes in Pseudomonas aeruginosa

Abstract:

Pseudomonas aeruginosa (P. aeruginosa), an obligatory aerobic non-fermented Gram-negative bacterium, is one of the common opportunistic pathogens of nosocomial infection. P. aeruginosa can cause severe infection such as respiratory tract, urinary tract, burn wounds and bacteremia. The antibiotic resistance of P. aeruginosa spread widely, which brings difficulties to clinical treatment. Essential genes are indispensable genes for organisms to grow. Investgation of P. aeruginosa essential genes could help us to understand the basic characteristics of bacteria such as growth and virulence, and could also help us to screen new targets of antibacterial agents. This paper will summary the progress of P. aeruginosa essential genes, including basic physiological characteristics of P. aeruginosa, the research methods of essential genes and the progress and significance of P. aeruginosa essential genes.

Key words:Pseudomonas aeruginosa, essential genes, transposon, bioinformatics, CRISPRi