Research progress on DNA compaction and replication of Hfq, a bacterial RNA binding protein

Abstract:

RNA-binding protein Hfq is an important post-transcription regulator of bacteria. Previous studies on Hfq mostly focused on the effects of this protein on small non-coding RNA (sRNA) and mRNA. The most typical function of Hfq is to promote the base pairing of sRNA with its target mRNA and mediate the regulation of RNA stability and translation after transcription. In addition, Hfq can interact directly or indirectly with a variety of proteins. However, recent studies have shown that in addition to RNA and proteins, Hfq can also interact with DNA and play a direct or indirect regulatory role in various DNA metabolism processes such as DNA compaction and DNA replication. Additional target and functional identification will further reinforce the importance of Hfq as a core regulator of multiple metabolic pathways in bacteria. It also indicates that the function of this protein is not limited to its role in RNA and protein metabolism. In this manuscript, the latest research progress of Hfq in the regulation of DNA metabolism in recent years is summarized and its prospect is prospected.

Key words:bacteria, Hfq, DNA compaction, DNA replication