Research progress of nuclear localization signal in virus infection mechanism

Abstract:

Nuclear localization signal-mediated protein entry into the nucleus is an important part of information exchange between the nucleus and the nucleus in the intracellular signal transmission network. Most viral proteins enter the nucleus in premise of being recognized by nuclear transport receptors and bound to the nuclear localization signals carried by viral proteins. The mechanism of important protein transport into the nucleus plays a vital role in the process of viral infection, and is of great significance for virus replication and virulence. The research on this mechanism is conducive to the discovery of new antiviral targets. This paper summarized the classification information of nuclear localization signals so as to conduct an analysis on comparisons of different nuclear transport receptors and their mediated entry mechanisms, and to sketch out the discovery of viral protein and its nuclear localization signal in the mechanism of viral infection.