Protein acetylation in bacteria

Abstract:

Post translational modification (PTM) refers to the precursors or proteins undergoing a series of processing modifications to form the protein with multiple functions. PTMs occur at distinct amino acid side chains or peptide linkages, and most are mediated by enzyme activity. Enzymes composed of 5% proteome mediate more than 200 types of post-translational modifications types, among which acetylation is an important PTM pathway. Acetylation modification is widely studied in eukaryotic organisms, it participates in almost all physiological activities of cells and is highly conserved. Many recent studies have shown that acetylation modification is also widespread in bacteria, and the researches related to physiological functions have also made significant progress. This article summarizes the mechanisms, functions of acetylation and detection technology of acetylation modification in bacteria. Besides, we analyze the existing problems and prospects the potential application value of acetylation modification.