Role of SrrAB in the growth, metabolism and viability of Staphylococcus: a review

Abstract:

The two-component signal transduction system SrrAB can sense the change of oxygen concentration in the external environment, affect the transcription of target genes through the change of phosphorylation level, and thus regulate a variety of biological characteristics of Staphylococcus. Studies have found that SrrAB is closely related to the virulence and biofilm formation of Staphylococcus, and the regulatory mechanisms under aerobic and anaerobic conditions are different. However, the role of SrrAB in staphylococcal growth and metabolism, and its mechanism in pathogen-host interaction remain unclear. Combined with the previous research of our laboratory, we reviewed the recent studies of SrrAB on the growth and metabolism in recent years, meanwhile, illuminated the interaction between SrrAB and innate immune cells so as to provide theoretical basis for the control of Staphylococcus infection.