Progress of outer membrane vesicles derived from Helicobacter pylori

Abstract:

Helicobacter pylori (H. pylori) infection is one of the factors that cause human gastric diseases. Outer membrane vesicles (OMVs) are vesicular structures formed by the spontaneous shedding of bacterial outer membrane, and have many components of outer membrane, including outer membrane proteins (OMPs), lipopolysaccharide (LPS), lipids and other protein components. Increasing studies were focusing on the biological function of OMVs in the development of H. pylori infection. Meanwhile, many researches showed that H. pylori OMVs act as vaccine candidate with the potential application in the prevention and treatment of H. pylori infection. Therefore, our review summarized the research progress on the components of OMVs derived from H. pylori, and discussed the potential functions of OMVs in the survival and pathogenesis of H. pylori, as well as the role of OMVs in the treatment of H. pylori infection.