Recent advances in carboxylic acid reductases

Abstract:

Carboxylic acid reductases (CARs) are capable of reducing carboxylic acids to the respective aldehydes under mild conditions, and have a broad substrate scope with no side products. Herein, we summarize recent advances in the research of phylogeny divergence, protein structure, catalytic mechanism and protein engineering of CARs, revealing its application prospect as an important tool enzyme in biological transformation and synthetic biology.

Key words:Carboxylic acid reductase, Phylogenesis, Protein structure, Catalytic mechanism, Molecular modification