Structure, function, and application of cytochrome P450 enzymes

Abstract:

Cytochrome P450 (CYP), membrane-bound hemoglobin enzymes, are widely present in microorganisms, animals, plants, and human. CYPs have a variety of biocatalytic activities such as oxidation, epoxidation hydroxylation, demethylation et al. Therefore, they play a key role in detoxification of biotin, cell metabolism and maintaining homeostasis. More importantly, the catalytic activity of CYPs is a hot issue in the fields of drug interaction and endocrine function. Furthermore, they are also widely utilized in the metabolism of drugs, carcinogens, steroids, fat-soluble vitamins and many other types of chemicals. This review provides a comprehensive overview of the structure, function, clinical application, and development prospects of CYPs. Besides, we aim to discuss the latest research and development prospects of CYPs.

Key words:Cytochrome P450, Reductase, Structure, Function, Genetic polymorphism