Research progress in inflammatory bowel disease and intestinal microecology

Abstract:

Inflammatory bowel disease (IBD) is an intestinal chronic inflammatory disease which pathogenesis is not yet clear. However, the incidence of IBD is increasing, which brings great financial burden to patients and their families. We need to find positive and effective treatments to help them. The latest view is that the balance between the host and the intestinal microorganism is broken, which triggers an immune inflammatory response in genetically susceptible individuals. Imbalance of intestinal flora plays an important role in the pathogenesis and development of IBD. Clinical studies found that IBD patients had varying degrees of intestinal flora imbalance. Combined application of probiotics can improve theses patient's symptoms. More and more researchers are paying close attention to the relationship between intestinal flora and IBD, and have carried out in-depth basic and clinical research. This article reviews the physiological influence of intestinal flora on IBD and the therapeutic effects of probiotics and fecal bacteria transplantation on IBD.