Research advances in Src and Abl tyrosine protein kinase family involved in pathogenic microbial infection

Abstract:

Src and Abl family kinases are the important members of the nonreceptor tyrosine kinase (NRTK) family, which exist widely in various cell types, participate in different intracellular signaling pathways, and regulate a variety of cellular physiological processes. They play a vital role in maintaining the homeostatic function of the normal cells, tissues and organs. Studies have shown that Src and Abl family kinases are involved in the infection with multiple pathogenic microorganisms through a variety of mechanisms (e.g. interaction with the proline motif-PXXP of the pathogenic microorganism). Therefore, the study of mechanism of pathogenesis of microbial pathogen infection from the perspective of Src and Abl family kinases has become a hot research issue. In this paper, the structural characteristics of Src and Abl family kinases and the reports on the relationship between microbial pathogen infection and host cell kinases are systematically reviewed, which should provide references for the research of pathogenic mechanism, prevention and control and drug development of pathogenic microorganisms.

Key words:Nonreceptor tyrosine kinase, Src, Abl, Microbial infection