Research advances on bacterial 3-oxoacyl-acyl carrier protein reductase

Abstract:

3-oxoacyl-acyl carrier protein reductase (FabG) are ubiquitously expressed enzymes that catalyse the reduction of acyl carrier protein (ACP) linked thioesters within the bacterial type II fatty acid synthesis (FASII) pathway, it reduce 3-oxoacyl-ACP to 3-hydroxyacyl-ACP, usually using NADPH as co-factor. FabG belongs to a broad superfamily of short-chain alcohol dehydrogenase/reductase or short-chain dehydrogenases/oxidoreductases (SDRs). The research reports of 3-oxoacyl-ACP reductase homologues in different bacteria show the characteristics of their diversity. However, in recent years, the summaries in this area have been very rare. In order to provide a theoretical reference for further research on 3-oxoacyl-ACP reductase, this review mainly summarizes the protein structures, function on fatty acid synthesis pathways and other biological functions of 3-oxoacyl-ACP reductase, antibiotics that target this enzyme.