Type III secretion system 2 pathogenicity islands of Escherichia coli

Abstract:

Many Gram-negative bacteria adhere to the surface of the host cell by means of the type III secretion system, and then inject the specific protein into the host cell across the membrane, destroying a variety of signal pathways in the host cell, which is beneficial to bacterial infection and colonization. In enteropathogenic Escherichia coli (EPEC), in addition to the intestinal cell shedding site (locus of entericyte effacement, LEE) virulence island encoded type III secretion system (T3SS), in the analysis of intestinal hemorrhagic Escherichia coli O157:H7 of the genome sequence found in a new type III secretion system, E. coli type III secretion system 2 (E. coli type III secretion system 2, ETT2) pathogenicity island. Studies have shown that ETT2 may not have a complete secretion system function in most strains, but it has an important effect on the virulence of bacteria. Therefore, this paper briefly reviews the genetic characteristics of E. coli ETT2, the distribution and prevalence of ETT2, the function and mechanism of ETT2 and other aspects of the main research progress.