Advance in Seneca valley virus epidemiology, diagnosis and control

Abstract:

Seneca valley virus (SVV) belongs to Senecavirus genus of family Picornaviridae, and is classified as the unique member of Senecavirus genus. SVV was identified in 2002 while cultivating viral vectors in PER.C6 cell culture and was suggested to be contaminated by fetal bovine serum or porcine trypsin. Many studies about SVV at the initial time have focused on the potential oncolytic activity of SVV in human cancer therapy. It is now identified as a pathogen to infect pigs and cause porcine idiopathic vesicular disease. The clinical signs include: cutaneous vesicular lesions on the snout and coronary bands, lameness, anorexia, lethargy and fever. These clinical signs are similar with that caused by foot-and-mouth disease, swine vesicular disease and vesicular stomatitis. Therefore, these diseases are indistinguishable by clinical signs. In 2015 to 2017, SVV infection occurred in the United States, China, Thailand and many other countries, with increasing spread and outbreaks. Therefore, urgent surveillance and control policies are needed to limit the spread of SVV. Several new diagnostic and control methods have been exploited. In the present review, we summarized the recent spread information, diagnostic and control methods of SVV to provide theoretical foundation for controlling of this disease.