Progress in morbillivirus-related autophagy

Abstract:

Autophagy is a complex intracellular biological process, which is regulated by a complex regulatory network involved in a large number of regulatory genes, and plays different roles depending on different tissues and organs, physiological and pathological states. In this review, the research progress in morbillivirus-related autophagy, especially the signal pathway of autophagy induced by the viruses is summarized. Studies on more than 20 families of viruses, and more than 50 different DNA or RNA viruses indicated that autophagy is a double-edged sword to a virus. In morbilliviruses, autophagy is critical for viral replication and spread. It was found that the viral H and F proteins are key molecules involved in morbillivirus-induced autophagy. Recent studies showed that measles virus could induce autophagy via IRGM, which is the key regulatory molecule in RNA virus-induced autophagy signaling pathway. CD46, a receptor of morbilliviruses, also plays a critical role in autophagy. In addition, there may be an important relationship between autophagy and immunosuppression caused by morbilliviruses.