Siderophore-antibiotic conjugates: the new antimicrobial agents

Abstract:

To find novel antimicrobial agents are becoming more and more important, since microbial pathogens have increased the resistance to antibiotic. One of reasonable factors is bacteria decreased the membrane permeability to drugs. Siderophore is a small molecular compound secreted by bacteria. After chelating iron, the Siderophore complex was bound by specific outer membrane receptor and transported into the cell. Similarly, the synthesized Siderophore-antibiotic conjugates can be recognized by bacteria and transported into the cell. As soon as the conjugates was transported into the cell, the antibiotic was released and killed the bacteria. Moreover, the conjugates also can prevent the bacteria get more iron. In this paper, we described the research progress of Siderophore-antibiotic conjugates as a novel antimicrobial agents. It will provide a theoretical basis for development of new antimicrobial agents and can help treat disease caused by antibiotic resistant disease.