The progress on drug resistance of Klebsiella pneumonia caused by efflux pump

Abstract:

Klebsiella pneumoniae is an important opportunistic pathogen and the rate of its nosocomial infection rises continuously. It has brought difficulties to therapy. Efflux pumps’ overexpression has been recently recognized as one of the most important mechanisms of drug resistance displayed by K. pneumoniae. The most important developments were introduced in this review, including the latest progress on the drug resistant profile of K. pneumoniae caused by efflux pumps, and the molecular structure and genetic regulation of efflux pumps. The inhibitors of efflux pumps and the roles of traditional Chinese medicine on drug resistant K. pneumoniae were also adressed in this review to provide some guides to treat infectious diseases caused by drug resistant pathogens.

Key words:Klebsiella pneumoniae (K. pneumoniae), Efflux pump, Drug resistance, Efflux pump inhibitors