Biological function and formation mechanism of phosphorylated viral protein

Abstract:

Phosphorylation is one of the most common post-translational modifications of viral proteins, which plays important roles in viral life cycle. The dynamic activities of viral proteins can be regulated by phosphorylation and dephosphorylation, which affect the cellular signal transduction for regulating some metabolism. Additionally, phosphorylation of viral proteins is involved in regulation of a series of viral metabolism, such as DNA replication, viral proliferation, assembly of virion and so on. Meanwhile, the phosphorylation of viral proteins has an effect on cellular signal transduction of hosts to inhibit DNA replication and gene expression of hosts. The phosphorylation sites, biological function and the molecular mechanism of its formation of various viral proteins were summarized in this review, which is helpful for controlling viral spread and development of new drug.