Effects of terC on antibiotics biosynthesis and mycelium development in Streptomyces coelicolor M145

Abstract:

[Objective] To study the function of terC (SCO2366) in Streptomyces coelicolor M145. [Methods] Through knocking out the terC in S. coelicolor M145, we detected its effects on actinorhodin biosynthesis and mycelium development. [Results] After knocking out the terC in S. coelicolor M145, the synthesis of actinorhodin began earlier than the wild type strain, and the length of mutant’s mycelium got shorter. [Conclusion] terC in S. coelicolor M145 has negative effect on actinorhodin biosynthesis, meanwhile affects mycelium development.