Advances on antimicrobial peptide engineering

Abstract:

Although antibiotics hold a leading position in the medical treatment and animal husbandry, but its prone-resistance to the pathogen lead to the rise of research and development of antimicrobial peptides (AMPs). As natural active substances, AMPs have antibacterial, antiviral, anti-tumor and immune regulation function, while the shortcomings such as short efficacy, sensitive to proteinase and high cytotoxicity limit its application. In this paper, the bottlenecks and their solution of antimicrobial peptide engineering were reviewed in terms of gene engineering, PEGylation, targeting and immobilization in order to promote the industrialization of AMPs.