The research progress of pexophagy in Pichia pastoris

Abstract:

Pexophagy is an important self-regulation mechanism. It is composed of various interactions by many autophagy related proteins (Atgs) according to strict spatial and temporal orders. Pichia pastoris was selected as the model to clarify the pexophagy mechanism for following reasons: two pexophagy modes, genome sequenced, and well-established gene manipulation protocols. In this review, the mechanism for Atgs involved in pexophagy activation, two pexophagy modes formation, and peroxisome degradation in vacuole of Pichia pastoris were organized, which provided a solid foundation for further research.

Key words:Pichia pastoris, Peroxisome, Autophagy, Autophagy related protein