Research advances of cellular iron transport and storage in Candida albicans

Abstract:

Candida albicans is one of the most important opportunistic pathogens. In order to adapt to the various ecological niches of the host, Candida albicans has evolved a variety of sophisticated metabolic strategies to maintain iron homeostasis, including multiple iron acquisition systems that target the cell membranes, and the mechanisms that coordinate intracellular iron trafficking. Here, combined with our study, we review the research advances of iron acquisition, storage and transportation strategies in recent years, focusing on intracellular iron storage and transport, especially the roles of mitochondria in cellular iron metabolism and homeostasis.