Progress in research on antibiotic resistance mechanisms of Helicobacter pylori

Abstract:

Helicobacter pylori (H. pylori) infection can cause peptic ulcer disease, gastric mucosa associated lymphoid tissue lymphoma (GMALTL) and even gastric cancer. With increasing problem of antibiotic resistance, study on mechanisms of which is promoted deeply. Molecular detection methods, especially the nucleic acid detection technologies, can be used to detect antibiotic resistance genes or mutations efficiently, rapidly and accurately, hence guiding the clinical treatment of H. pylori infection and helping to investigate antibiotic resistance rate timely and effectively in a large area. In this review, H. pylori antibiotic resistance mechanisms of the most commonly used antibiotics were discussed and associated resistance genes or mutations were emphatically reviewed.