Advances on resveratrol production of engineered microorganisms

Abstract:

Resveratrol, a plant-derived polyphenolic compound, has significant physiological activities, including scavenging free radicals, antioxidant and extending lifespan. It has a pleasing market for health products, cosmetics and medicines. At present, resveratrol is mainly extracted from plant, which is limited by the low concentration and extraction efficiency. The rapid development of synthetic biology gives a new approach to produce resveratrol using microogrganisms. Resveratrol has been biosynthesized through introducing exogenous genes into microorganisms. Moreover, the recombinant strains are optimized in encoding sequences and combination of genes with suitable fermentation process control. This paper outlines the research achievement on resveratrol production in engineered microorganisms.