Industrial antibiotic-producing actinobacteria: from strain improvement to bioprocess optimization and scale-up

Abstract:

Actinobacteria are well known as they can produce a series of secondary metabolites with complex structures and various bioactivities. The industrial production of these secondary metabolites plays a vital role in medical and agricultural fields. Recent advances in strain improvement, bioprocess optimization and control, and fermentation scale-up were reviewed here. The holistic viewpoints and approaches applied in industrialized production of secondary metabolites by actinobacteria were discussed as well as the perspectives.

Key words:Actinobacteria, Strain improvement, Bioprocess optimization, Fermentation scale-up