The roles of polyamines on pathogenesis of bacterial pathogens

Abstract:

Polyamines are aliphatic compounds with two or more amino groups. The intracellular content of polyamines is regulated by the biosynthesis, transport, degradation and interconversion processes. The polyamines and their biosynthesis and transport mechanisms have important roles on the pathogenesis of bacterial pathogens. This review focuses on the roles of polyamines on the transcription and translation of virulence factors of bacteria, the formation of biofilm, the resistance to antibiotics, the resistance to the acid stress and oxidative stress in host, the biosynthesis of molecules involved in pathogenesis and the resistance to the host.