Advances in photonic detection of Salmonella typhimurium in vivo

Abstract:

Study on Salmonella typhimurium (S. typhimurium) pathogenesis in vivo is significant for control of food poisoning, gastroenteritis, typhoid fever and other intestinal infectious diseases. Because it is difficult to detect dynamic changes for S. typhimurium in living hosts, the strategy for preventation and treatment of Salmonellosis as well as the development of drug and vaccine production are restricted. In recent years, small animal imaging technology is widely used to track bioluminescent Salmonella typhimurium (S. typh-lux) in vivo. The present article summarizes the merit and shortage of the application of small animal imaging.