The measures of avoiding complement attack in Baculovirus-mediated gene delivery

Abstract:

Serum complement system is the signi?cant barrier to the development of baculovirus vectors for therapeutic gene delivery. This paper gave a review to the efforts taken to avoid complement attack. Selecting the immunoprivileged tissues as target for baculovirus-mediated gene delivery, such as eye, brain and testis. ex vivo transduction is a widely used approach to exclude the complement attack. Using of pharmacological inhibitors of complement as well as surface engineering of the baculoviral vectors through the use of synthetic polymers, pseudotyping or display of complement inhibitors can inhibit complement attack efficiently. This will signi?cantly increase the possibility of using baculovirus vectors for therapeutic applications.

Key words:Baculoviruses, AcMNPV, Complement, Gene delivery