Developments towards antiviral agents and vaccine against enterovirus 71

Abstract:

Hand, foot, and mouth disease (HFMD) outbreaks have been reported in many areas, especially in Aria. Enterovirus 71 (EV71) is the major causative pathogen of HFMD in children and infants, its infection usually accompanied with severe neurological complication which causes high mortality. In recent years, the molecular biology study of EV71 and the progress of antiviral therapies development provide us new strategies for the treatment and prevention of EV71 infection. This paper reviewed the latest achievements in virology and antiviral agents of EV71, including drugs, vaccine, and RNA interference etc, which may be expected to serve as references for related research.