Advances in multidrug resistance transporter Bmr of Bacillus subtilis and transcriptional regulation mechanism of its gene bmr

Abstract:

Multidrug transporter Bmr is one of the main drug resistance efflux proteins in Bacillus subtilis. It’s encoded by bmr gene which is located in the genome, and it mediates the resistance to a wide range of drugs such as antibiotics and antimicrobials, etc. The expression of bmr gene is regulated by BmrR and MtaN, both of which are transcriptional regulator from the MerR family. This paper reviewed the study of structure, physiological function and the action mechanism of Bmr and the regulatory protein BmrR and MtaN in recent years.

Key words:Multidrug resistance, Bmr, BmrR, MtaN, Transcriptional regulation