Pharmacodynamics effect of enrofloxacin on four aquatic pathogenic vibrio

Abstract:

The minimal inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of enrofloxacin against 12 strains of Vibrio alginolyticus, V. mimicus, V. harveyi, V. vulnificus were determined by two-fold broth macrodilution method and the results showed that the MIC and MBC were 0.1?0.8 mg/L and 0.4?3.2 mg/L respectively. On the basis of these, 4 sensitive strains of 12 vibrio srtains were measured with the killing-curves and the PAE in different concentrations of enrofloxacin. The results showed that every concentration of enrofloxacin against V. alginolyticus X040625-R had a strong antibactericidal effect, but that against V. harveyi M071202-H, V. vulnificus Q050723-C, V. mimicus H010911-Z showed that the three bacteria was inhibited in the lower concentration and gradually killed with the increasing concentration. The PAE of enrofloxacin had a direct relationship with the concentration and the mixing time of the drug. The PAE of enrofloxacin against V. alginolyticus X040625-R was the longest while that against V. harveyi M071202-H was the shortest.