The effect of Levofloxacin on Streptococcus pneumoniae D39 revealed by comparative proteomics

Abstract:

The protein expression levels of Streptococcus pneumoniae D39 upon Levofloxacin treatment were studied using comparative proteomics method. In total, 23 differentially expressed proteins were identified via mass spectrometry. These proteins mainly involved in the DNA replication, transcription and protein translation. This study provides important information to the molecular mechanism of antibiotics actions and the drug resistance of bacteria.