Screening and identification of a novel γ-polyglutamic acid producing strain

Abstract:

A novel γ-polyglutamic acid (γ-PGA) producing-strain Bacillus subtilis PGS-1 was isolated from soil, which could produced a large mount of γ-PGA in the medium containing glucose and glutamate. The highest yield 26 g/L of γ-PGA was obtained in flask culture. Compared with other reported γ-PGA producing-strain, γ-PGA derived from Bacillus subtilis PGS-1 had a lower molecular weight (3×10⁵?4×10⁵ kD) and a narrower polydispersity (1.3?2.0), which could endow γ-PGA a promising application, such as in the drug delivery system.