The System of Integron-gene Cassettes and β-Lactamase Mediated Antibiotic Resistance

Abstract:

Integrons are novel DNA elements, which can capture and incorporate gene cassettes embedded in exogenous by site-specific recombination. Meanwhile, they are able to convent gene cassettes to functional genes by ensuring their correct expression. The horizontal transfer of this genetic element within and between microbial genera has speeded up emergence of novel antibiotic resistance gene. To date, the mechanism of resistance to antibiotics, particularly β-Lactam class of antibiotic, is becoming exceedingly complex. What is more, multi-drug resistant microbes with complex resistance patterns have posed an increasing threat to the health. So intensive research leading to greater understanding is imperative.

Key words:Integron, Horizontal gene transfer, Beta-Lactamase, Mechanisms of antibiotic resistance, Gene cassettes