The Relationship Between Glutathione and the Pathogenicity of Pseudomonas aeruginosa

Abstract:

Pseudomonas aeruginosa is one of the most common causes of nosocomial infection due to its intrinsic resistance to antibiotics. In the host, glutathione (GSH), one of the most important intracellular antioxidants, provides protection against high levels of oxidative stress. A decrease in GSH levels in tissues infected with P. aeruginosa has been observed while interactions between pyocyanin and GSH maybe partially attribute to P. aeruginosa infection. In this review, the relationship between GSH and the pathogenicity of P. aeruginosa has been discussed based on the author’s own research results and the latest literature.