Kinetics of Streptomyces fradiae HTP6 in the Batch Fermentation Process

Abstract:

The kinetics of neomycin productions by batch fermentation with Streptomyces fradiae HTP6 were studied. The mathematical kinetic models describing the course of Streptomyces fradiae HTP6 fermentation were established. The maximal specific growth rate μm was 0.0866 h-1 in exponential phase. The maximal specific production rate qp could reach 1.1867×10-4 g/(mL·h) in antibiotic production phase. The calculated results of models were compared satisfactorily with experimental data, the average relative deviation was no more than 5%. This kinetic model had practically guiding producing neomycin in fermentation of Streptomyces fradiae.

Key words:Streptomyces fradiae, Neomycin, Fermentation, Kinetics model