Phospholipase D and Pathogenic Microorganisms Invasion

Abstract:

Phospholipase D (PLD) is ubiquitous in bacteria, fungi, and mammal. In pathogenic microorganisms, PLD can be pathogenic determinant and play a role in spore generation. In mammalian cells, PLD functions in several signal transduction pathways, such as membrane transportation, mitosis regulation, and actin cytoskeleton regulation. In the process of pathogens invasion host cells, both of the pathogen and host cells’ PLD will be activated and a series of cascade reaction will be generated. During this process, pathogen’s PLD can regulate the polymerization and reorganization of its own actin filaments and induce the polymerization or reorganization of the host cell actin filaments near the foci, thus to promote the phagocytosis of the pathogen by host cell. Investigating the role of PLD activation in the infection will be significance for further understanding the molecular mechanism of pathogen-host cell interaction.